Burnley beat Blackburn Rovers 2-0 at Ewood Park in their East Lancashire derby but Premier League sides Southampton and Newcastle United crashed out of the English League Cup to Championship opposition in Wednesday's second-round games.
Champions Chelsea have not enjoyed the best of starts at home this season and face their biggest test yet on Saturday with the visit of free-scoring leaders Manchester City.
Manchester United will travel to third-tier MK Dons in the Capital One Cup second round following the draw on Wednesday, the first time they have been involved at this stage of the competition for 19 years.
Mohamed Salah was inevitably on the scoresheet as Liverpool took full advantage of the inactivity of their top-four rivals to thrash West Ham United 4-1 at Anfield and provisionally move into second in the Premier League.
Chelsea's new signing Gonzalo Higuain netted his first two Premier League goals in Chelsea's 5-0 thrashing of Huddersfield Town while Tottenham Hotspur's Son Heung-min struck late for a 1-0 win over Newcastle United as they moved into second place.
United beat Leicester City at Old Trafford in the opening game of the season but Spurs present a very different quality of opponent.
Leeds United were crowned champions of the second-tier Championship after third-placed Brentford lost 1-0 at Stoke City in their penultimate game of the season on Saturday.
Following is a match by match look at the English Premier League's weekend fixtures:
Tottenham Hotspur's status as Premier League title chasers was seriously harmed on Saturday as they fell to a first defeat in seven league games, losing the lead to go down 3-1 at home to Wolverhampton Wanderers.
Minor league Lincoln City produced a huge FA Cup shock to beat top-flight Burnley 1-0 and reach the quarter-finals for the first time in their history on Saturday.
"Chelsea Football Club and Antonio Conte have parted company," the London outfit said on their website.
Here are five talking points from the weekend's Premier League action:
Manchester United midfielder Paul Pogba has thanked Jose Mourinho for helping him 'improve as a person' despite the breakdown of their relationship in the last few months leading up to the former manager's sacking on Tuesday.
English champions and runners-up since the league restarted in the 1946-47 season after World War Two:
'I co-operated excellently with him at Chelsea, and the fact that Mourinho is the coach at Manchester was the decisive factor in my choosing my new environment'
Chelsea named former Napoli boss Maurizio Sarri as the new head coach on a three-year term on Saturday, a day after parting ways with another Italian manager Antonio Conte.
'We haven't managed to get ourselves in the top four. We needed other teams to help us out and we needed to help ourselves and we haven't done that'
News of all that's transpired on and off the football field
'It's only 13 games in, that's the most important thing and there's so many points to be won. You need to carry on for 38 games and show consistency'
Romelu Lukaku extended his impressive FA Cup scoring record by netting twice in Manchester United's 2-0 win at Huddersfield Town to earn Jose Mourinho's side a quarter-final tie at home to Brighton & Hove Albion.
Chelsea to host Burnley in Premier League season ope
The victory puts the pressure back on title rivals Liverpool who are at Cardiff City on Sunday and trail by a point with each side having played 34 games.
The 27-year-old Belgium international had joined City squad last week after helping his country progress to the World Cup semi-finals in Russia.
Mourinho's tinkerings meant a first start of the season for midfielder Scott McTominay, playing on the right of a three-man defence, while Anthony Martial played instead of the dropped Alexis Sanchez. On this evidence, more changes may be needed when United take on Valencia in the Champions League on Tuesday.
Chelsea's players must quickly adapt to new manager Maurizio Sarri's demands as the Italian looks to reshape the team for the new Premier League season
Chelsea coach Maurizio Sarri wants to keep Belgian forward Eden Hazard at the Premier League club and improve him as a player.
The Spaniard has made a number of uncharacteristic mistakes in recent games, including one that allowed Chelsea to equalise in Sunday's 1-1 draw.
Arsenal midfielder Aaron Ramsey says he has yet to reach an agreement with the Premier League club about his future. The Wales international, who joined the club in 2008, is in the final year of his contract.
Following is a match by match look at the English Premier League's weekend fixtures:
West Ham had lost their first three Premier League games to sit bottom of the table and their dismal start to the campaign had already sparked speculation among pundits as to whether new manager Manuel Pellegrini would see out the season.
News of all that's transpired on and off the football field
Images from the EPL matches played on Sunday
Riyad Mahrez scored one and set up another as Leicester City strolled to a 3-0 win over Huddersfield Town in the Premier League on Monday.
Five talking-points from the Premier League weekend after Manchester City suffered a shock home loss to Crystal Palace, meaning that Liverpool stayed four points clear at the top following their win over Wolverhampton Wanderers.
Manchester United's troubled season hit a new low on Saturday as Jose Mourinho saw his gamble on introducing a new tactical system backfire with an insipid 3-1 defeat to West Ham United in the Premier League.
Rediff.com encapsulates all the sporting action from the past week in this eye-catching photo feature.
Failing to sign Cristiano Ronaldo is outgoing Arsenal manager Arsene Wenger's biggest transfer regret
A night of wholesale team changes for the 11 Premier League sides in action produced one notable upset with top flight Stoke City losing 2-0 at second-tier Bristol City.
Two big derbies and an eventful weekend of football awaits us all...
Images from the English Premier League matches played on Wednesday
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